icone Mucus

  Articles

Lacroix iScience

A porous cervical mucus plug leads to preterm birth induced by experimental vaginal infection in mice
Lacroix G, Gouyer V, Rocher M, Gottrand F, Desseyn JL
iScience 2022;25(7):104526. doi:10.1016/j.isci.2022.104526


2020 Hueso

Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: The role of mucosal strengthening
Hueso T, Ekpe K, Mayeur C, Gatse A, Joncquel-Chevallier Curt M, Gricourt G, Rodriguez C, Burdet C, Ulmann G, Neut C, Amini SE, Lepage P, Raynard B, Willekens C, Micol JB, De Botton S, Yakoub-Agha I, Gottrand F, Desseyn JL, Thomas M, Woerther PL, Seguy D
Gut Microbes 2020;12(1):e1800897. doi:1080/19490976.2020.1800897


FG 2020 Fasquelle

Importance of the Phospholipid Core for Mucin Hydrogel Penetration and Mucosal Cell Uptake of Maltodextrin Nanoparticles
Fasquelle F, Carpentier R, Demouveaux B, Desseyn JL, Betbeder D
ACS Appl Bio Mater 2020;3(9):5741-5749. doi:10.1021/acsabm.0c00521


demouveaux_2019_SciRep

Mucin CYS domain stiffens the mucus gel hindering bacteria and spermatozoa
Demouveaux B, Gouyer V, Robbe-Masselot C, Gottrand F, Narita T, Desseyn JL
Sci Rep 2019;9(1):16993. doi:10.1038/s41598-019-53547-x


Ley_2019_SciRep

Early life nutrition influences susceptibility to chronic inflammatory colitis in later life
Ley D, Desseyn JL, Gouyer V, Plet S, Tims S, Renes I, Mischke m, Gottrand F
Sci Rep 2019;9(1):18111. doi:10.1038/s41598-019-54308-6


Valque_2019_Bio

Muc5b-deficient mice develop early histological lung abnormalities
Valque H, Gouyer V, Duez C, Leboeuf C, Marquillies P, Le Bert M, Plet S, Ryffel B, Janin A, Gottrand F, Desseyn JL
Biol Open 2019;8(11):bio046359. doi:10.1242/bio.046359


Amini 2019 HCB

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium
Amini S-E, Gouyer V, Portal C, Gottrand F, Desseyn JL
Histochem Cell Biol 2019;152:167-174. doi:10.1007/s00418-019-01785-5


BBRC2018-Mucin C-mannosylation

Non-C-mannosylable mucin CYS domains hindered proper folding and secretion of mucin
Gouyer V, Demouveaux B, Lacroix G, Valque H, Gottrand F, Desseyn JL
BBRC 2018;506(4):812-818. doi:10.1016/j.bbrc.2018.10.138


Portal 2018 PLoS1

Long-term dietary (n-3) polyunsaturated fatty acids show benefits to the lungs of Cftr F508del mice
Portal C, Gouyer V, Léonard R, Husson MO, Gottrand F, Desseyn JL
PLoS One 2018;13(6):e0197808. doi:10.1371/journal.pone.0197808


CellMicrob 2018

Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut
Znaidi S, van Wijlick L, Hernández‐Cervantes A, Sertour N, Desseyn JL, Vincent F, Atanassova R, Gouyer V, Munro CA, Bachellier‐Bassi S, Dalle F, Jouault T, Bougnoux ME, d'Enfert C
Cell Microbiol 2018;20(11):e12890. doi:10.1111/cmi.12890


Portal 2017

In vivo imaging of the Muc5b gel-forming mucin
Portal C, Gouyer V, Magnien M, Plet S, Gottrand F, Desseyn JL
Sci Rep 2017;7:44591. doi:10.1038/srep44591


Portal 2017 2

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatmentsPortal C, Gouyer V, Gottrand F, Desseyn JL
PLoS One 2017;12(3):e0174764. doi:10.1371/journal.pone.0174764


Sci Rep 2015 1

Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier
Gouyer V, Dubuquoy L, Robbe-Masselot C, Neut C, Singer E, Plet S, Geboes K, Desreumaux P, Gottrand F, Desseyn JL
Sci Rep 2015;5:9577. doi:10.1038/srep09577


J Infec Dis

Dietary pectin-derived acidic oligosaccharides improve the pulmonary bacterial clearance of Pseudomonas aeruginosa lung infection in mice by modulating intestinal microbiota and immunity
Bernard H, Desseyn JL, Bartke N, Kleinjans L, Stahl B, Belzer C, Knol J, Gottrand F, Husson MO
J Infect Dis 2015;211(1):156-165. doi: 10.1093/infdis/jiu391


Br J Nutr

Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection
Caron E, Desseyn JL, Sergent L, Bartke N, Husson MO, Duhamel A, Gottrand F
Br J Nutr 2015;113(2):191-199. doi: 10.1017/S0007114514003705


2015 PloS One

Pectin-Derived Acidic Oligosaccharides Improve the Outcome of Pseudomonas aeruginosa Lung Infection in C57BL/6 Mice
Bernard H, Desseyn JL, Gottrand F, Stahl B, Bartke N, Husson MO
PLoS One 2015;10(11):e0139686. doi:10.1371/journal.pone.0139686


JBC Thornton 2014

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin
Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ
J Biol Chem 2014;289(23):16409-16420. doi: 10.1074/jbc.M114.566679


PloS 1 2012

MUC5B leads to aggressive behavior of breast cancer MCF7 cells
Valque H, Gouyer V, Gottrand F, Desseyn JL
PLoS One 2012;7(10):e46699. doi:10.1371/journal.pone.0046699


Jonckheere 2012

The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways
Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frénois F, Van Seuningen I
PLoS One 2012;7(2):e32232. doi:10.1371/journal.pone.0032232


HCB 2011

Abnormal expression of Muc5b in Cftr-null mice and in mammary tumors of MMTV-ras mice
Valque H, Gouyer V, Husson MO, Gottrand F, Desseyn JL
Histochem Cell Biol 2011;136(6):699-708. doi:10.1007/s00418-011-0872-5


J nutr 2011

(n-3) long-chain PUFA differentially affect resistance to Pseudomonas aeruginosa infection of male and female cftr–/– miceTiesset H, Bernard H, Bartke N, Beermann C, Flachaire E, Desseyn JL, Gottrand F, Husson MO
J Nutr 2011;141(6):1101-1107. doi:10.3945/jn.110.134585


PloS 1 2011

The extraordinarily complex but highly structured organization of intestinal mucus-gel unveiled in multicolor images
Gouyer V, Gottrand F, Desseyn JL
PLoS One 2011;6(4):e18761. doi:10.1371/journal.pone.0018761


HCB 2010

The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice
Gouyer V, Leir SH, Tetaert D, Liu Y, Gottrand F, Harris A, Desseyn JL
Histochem Cell Biol 2010;133(5):517-525. doi:10.1007/s00418-010-0688-8


J Nutr 2009

Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro- and antiinflammatory responses in mice with Pseudomonas aeruginosa lung infection
Tiesset H, Pierre M, Desseyn JL, Guéry B, Beermann C, Galabert C, Gottrand F, Husson MO
J Nutr 2009;139(1):82-89. doi: 10.3945/jn.108.096115


2009 MPE

Mucin CYS domains are ancient and highly conserved modules that evolved in concert
Desseyn JL
Mol Phylogenet Evol 2009;52(2):284-292. doi:10.1016/j.ympev.2009.03.035


2009 BBA

A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening
Palmieri-Thiers C, Canaan S, Brunini V, Lorenzi V, Tomi F, Desseyn JL, Garscha U, Oliw EH, Berti L, Maury J
Biochim Biophys Acta 2009;1791(5):339-346. doi:10.1016/j.bbalip.2009.02.012

Oncogene 2008

Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells
Gouyer V, Fontaine D, Dumont P, de Wever O, Fontayne-Devaud H, Leteurtre E, Truant S, Delacour D, Drobecq H, Kerckaert JP, de Launoit Y, Bracke M, Gespach C, Desseyn JL, Huet G
Oncogene 2008;27(29):4024-4033. doi: 10.1038/onc.2008.42


2007 AJP

Omega-3 polyunsaturated fatty acids improve host response in chronic Pseudomonas aeruginosa lung infection in mice
Pierre M, Husson MO, Le Berre R, Desseyn JL, Galabert C, Béghin L, Beermann C, Gagenais A, Berthiaume Y, Cardinaud B, Barbry P, Gottrand F, Guery B
Am J Physiol Lung Cell Mol Physiol 2007;292(6):L1422-L1431. doi:10.1152/ajplung.00337.2006


2007 Resp Res

Dietary n-3 fatty acids have suppressive effects on mucin upregulation in mice infected with Pseudomonas aeruginosa
Tetaert D, Pierre M, Demeyer D, Husson MO, Béghin L, Galabert C, Gottrand F, Beermann C, Guery B, Desseyn JL
Respir Res 2007;8:39. doi:10.1186/1465-9921-8-39


2007 Oncogene

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells
Vincent A, Perrais M, Desseyn JL, Aubert JP, Pigny P, Van Seuningen I
Oncogene 2007;26(5):6566-6576. doi:MUC5B10.1038/sj.onc.1210479


Genomics

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse
Desseyn JL, Laine A
Genomics 2003;81(4):433-436. doi:10.1016/s0888-7543(03)00036-3


Eur J Biochem_1999

Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4
Desseyn JL, Clavereau I, Laine A
Eur J Biochem 2002;269(13):3150-3159. doi:10.1046/j.1432-1033.2002.02988.x


Mol Biol Evol 2000

Evolution of the large secreted gel-forming mucins
Desseyn JL, Aubert JP, Porchet N, Laine A
Mol Biol Evol 2000;17(8):1175-1184. doi:10.1093/oxfordjournals.molbev.a026400


PNAS 2000

Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development
Desseyn JL, Burton KA, McKnight GS
Proc Natl Acad Sci USA 2000;97(12):6433-3438. doi:10.1073/pnas.97.12.6433


Electrophoresis 1999

Fifty-nine bp repeat polymorphism in the uncommon intron 36 of the human mucin gene MUC5B
Desseyn JL, Rousseau K, Laine A
Electrophoresis 1999;20(3):493-496. doi:10.1002/(SICI)1522-2683(19990301)20:3


JBC 1998 Desseyn

Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon
Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A
J Biol Chem 1998;273(46):30157-30164. doi:10.1074/jbc.273.46.30157


JBC 1998 Desseyn

Evolutionary history of the 11p15 human mucin gene family
Desseyn JL, Buisine MP, Porchet N, Aubert JP, Degand P, Laine A
J Mol Evol 1998;46(1):102-106. doi:10.1007/pl00006276


BJ 1998 Buisine

Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family
Buisine MP, Desseyn JL, Porchet N, Degand P, Laine A, Aubert JP
Biochem J 1998;332(Pt3):729-738. doi:10.1042/bj3320729


JBC 1997 Desseyn

Genomic organization of the 3' region of the human mucin gene MUC5B
Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A
J Biol Chem 1997;272(27):16873-16883. doi:10.1074/jbc.272.27.16873


JBC Desseyn 1997

Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family
Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A
J Biol Chem 1997;272(6):3168-3178. doi:10.1074/jbc.272.6.3168


BBRC 1996 Pigny

Identification of a 42-kDa nuclear factor (NF1-MUC5B) from HT-29 MTX cells that binds to the 3' region of human mucin gene MUC5B
Pigny P, Van Seuningen P, Desseyn JL, Nollet S, Porchet N, Laine A, Aubert JP
Biochem Biophys Res Commun 1996;220(1):186-191. doi:10.1006/bbrc.1996.0378