Activities

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A structure of excellence dedicated to research and education on inflammation. LIRIC is an effective European research and training center working hand-in-hand with industrials in order to achieve excellence in terms of research, training, job creation and economy.

Research

LIRIC promotes a transversal and collaborative approach to research within the teams.

The work of our teams is regularly published in leading international scientific journals, with strong impact factors. Over the last 5 years, the LIRIC teams have written more than 1,500 scientific publications. These publications, often co-signed by several teams of the LIRIC Center, reflect the diversity of our specialists and the transversal nature of their work.

Our publications fall into several clinical fields: gastroenterology, hepatology, internal medicine, microbiology, immunology, neurology, nephrology, transplants, respiratory, yeasts and nutrition.

Each team shares their progress and challenges during weekly and monthly meetings held in the center. This approach multiplies the perspectives and spurs the creativity of the teams.

The center conducts excellent translational research based on large cohorts of adult and pediatric patients (IBD, liver diseases, multiple sclerosis, eosinophilia, fungal diseases, cystic fibrosis, kidney and bone marrow transplant). Substantial contributions have been made to national and international therapeutic studies, most particularly in IBD, alcoholic cirrhosis and multiple sclerosis, published in journals with a high impact factor. Significant contributions have also been made in epidemiology, based on the EPIMAD registry, the world’s largest population-based registry for IBDs.

Key Figures

  • 4.5 million euros worth of national and international research projects supported over 4 years
  • 58 clinical trials coordinated or conducted
  • 8 international congresses organized
  • 100 invited lectures
  • > 1,500 publications over the last 5 years
  • 24 projects conducted with industrials for a total budget of €1.3 million
  • 20 Ph.D. theses defended in 3 years
  • 27 Ph.D. in progress
  • 23 filed patents
  • 5 molecules in phase I or II of development

Innovation

Chercheur

The LIRIC scientific work opens up a wide array of innovation possibilities for health industries, thanks to a very open structure and an effective management of industrial property and industrial partnerships.

Patent registration is provided by SATT Nord (technology transfer office) and Inserm Transfert. Several partners of LIRIC benefit from the support of the Nutrition Health Longevity Competitiveness Cluster.

LIRIC also offers specific innovation services, provided by a biotechnology company born from our teams’ work: Intestinal Biotech Development (IBD) specialized in digestive diseases.

LIRIC activities also led to the launching of Vaxinano in 2016, a company that develops vaccine solutions from a unique and innovative system of antigen distribution using biocompatible nanoparticles.

In October 2017, creation of the start-up Par’Immune, dedicated to the scientific, clinical and commercial development of therapies based on a parasitic protein as a new immunotherapeutic strategy for autoimmune and inflammatory diseases.

Support for health care professionals

Chercheur

LIRIC maintains close relationships with the gastro-enterologists with liberal practice and physicians at hospital. Objective: to make our research advances as available as possible.

  • Annual clinical program, in collaboration with GETAID, the DigestScience Foundation and the pharma industry.
  • Monthly meetings of researchers with gastroenterologists, to discuss the most complex IBD cases.
  • Online training (http://www.diumici.org), developed in collaboration with GETAID and the universities of Lille and Paris VI, with over 800 trained health professionals.
  • International scientific workshops, organized with the support of the DigestScience Foundation

Training and Education

Groupe

The training of researchers and clinicians to and through research is a priority in our work. All LIRIC teams are affiliated to the Doctoral School ED446 Biology-Health in Lille. Twenty Ph.D. thesis have been defended over the last 3 years and 27 are in progress.

LIRIC welcomes many students for their Master 2, Master 1, Bachelor, BTS, or University Degree (DU) internships.

LIRIC helps organize an international degree (DIU) on inflammatory bowel diseases. It also coordinates a Master Degree on drug design (http://pharmacie.univ-lille2.fr/etudes-pharmaceutiques/les-masters.html). One of its teams is co-responsible for the University Degree (DU) on Longevity (https://www.pasteur-lille.fr/formation-sante/du-longevite/).

LIRIC set up several Master level trainings focused on inflammation and organized many high-level scientific workshops, with the support of the DigestScience Foundation. Our objective is to train as many researchers and health care professionals as possible to the most recent scientific advances.

It is also to have tomorrow’s leaders, at an international level, take part in our research in the areas of biology, pharmacy, medicine, and engineering.