Nutritional modulation of inflammation

Workpackage: WP1

Research topics

Our work focuses on the mechanisms of action and regulation of nutritional and environmental factors in inflammatory and infectious processes. We at seeking to better understand how inflammation can be modulated in epithelial pathologies, and to develop new clinical approaches for these conditions.

Our main scientific objectives are to show that:
-nutrition in early life can prevent inflammation in the lung and the intestine
-nutritional intervention can reverse GVHr reaction.

Main publications

Early-life origin of intestinal inflammatory disorders
Ley D, Desseyn JL, Mischke M, Knol J, Turck D, Gottrand F
Nutr. Rev. 2017 75(3):175-187

Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids
Husson MO, Ley D, Portal C, Gottrand M, Hueso T, Desseyn JL, Gottrand F
J. Infect. 2016 73(6):523-535

Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study
Hochart A, Gower-Rousseau C, Sarter H, Fumery M, Ley D, Spyckerelle C, Peyrin-Biroulet L, Laberenne JE, Vasseur F, Savoye G, Turck D; Epimad Group
Gut. 2016 66(11):1912-1917

Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia
Schneider A, Gottrand F, Bellaiche M, Becmeur F, Lachaux A, Bridoux-Henno L, Michel JL, Faure C, Philippe P, Vandenplas Y, Dupont C, Breton A, Gaudin J, Lamireau T, Muyshont L, Podevin G, Viola S, Bertrand V, Caldari D, Colinet S, Wanty C, Sauleau E, Leteurtre E, Michaud L
Ann Surg. 2016;264(6):1004-1008

ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis
Turck D, Braegger CP, Colombo C, Declercq D, Morton A, Pancheva R, Robberecht E, Stern M, Strandvik B, Wolfe S, Schneider SM, Wilschanski M
Clin Nutr. 2016;35(3):557-77

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