Immunity, Inflammation and Fibrosis in Auto- and Allo-Reactivity

Our research activities aim at understanding the pathophysiology of auto- and alloimmune inflammatory diseases and their complications, especially fibrosis.  The team is composed of 2 groups : NEMESIS (multilple sclerosis and neuroinflammatory diseases), and FIRE (role of the immune system in fibrosis of inflammatory diseases, especially SSc and cGvHD)

Lines of research

Our research activities are divided in two groups:

  • Fire group:

  • Nemesis group:


Close collaboration with the clinical teams

Our research teams work in close collaboration with the clinical departments of Neurology, Internal Medicine and Hematology at Lille University Hospital in the framework of the FHU IMMINeNT.

Such close work with health care teams allows us to develop translational and clinical research, further reinforced by the contributions of the Institute of Clinical Immunology (Institut d’immunologie clinique).

Our research program benefits from direct access to a significant cohort of patients treated by our clinical partners.

Main publications

FIRE : Scientific articles


2018
1. Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zephir H, Vermersch P, Labalette M, Launay D, Dubucquoi S*. Altered B lymphocyte homeostasis and functions in systemic sclerosis. Autoimmun Rev 2018 Mar;17(3):244-255. (IF : 8.961)

2. Guerrier T, Labalette M, Launay D, Lee-Chang C, Outteryck O, Lefèvre G, Vermersch P, Dubucquoi S, Zéphir H. Proinflammatory B-cell profile in the early phases of MS predicts an active disease. Neurol Neuroimmunol Neuroinflamm 2018;5:e431. (IF Neurology 8.320)

3. Jouvray M, Launay D, Dubucquoi S, Sobanski V, Podevin C, Lambert M, Morell-Dubois S, Maillard H, Hatron PY, Hachulla E, Giovannelli J*. Whole-Body Distribution and Clinical Association of Telangiectases in Systemic Sclerosis. JAMA Dermatol 2018 (in press). (IF : 5.82)

4. Grunewald O, Lopez B, Brabant S, Rogeau S, Deschildre A, Phrommavanh V, Lefort M, Moitrot E, Gyselinckx D, Deleplancque AS, Lefèvre G, Labalette M, Dubucquoi S.* Immunoglobulin G (IgG) and IgG subclass reference intervals in children, using Optilite® reagents. Clin Chem Lab Med. 2018 (IF : 3,432)

2017

5. Sanges S, Jendoubi M, Kavian N, Hauspie C, Speca S, Crave JC, Guerrier T, Lefèvre G, Sobanski V, Savina A, Hachulla E, Hatron PY, Labalette M, Batteux F, Dubucquoi S, Launay D*. B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis. Front Immunol 2017;8. (IF : 6.429)

2016

6. Sobanski V, Giovannelli J, Lynch BM, Schreiber BE, Nihtyanova SI, Harvey J, Handler CE, Denton CP, Coghlan JG. Characteristics and Survival of Anti-U1 RNP Antibody-Positive Patients With Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.. Arthritis Rheumatol. 2016; 68:484-93. (IF : 6,918)

7. Bertin D, Dubucquoi S, Lakomy D, Deleplancque AS, Desplat-Jégo S. Diagnostic performance of a new vimentin-derived ACPA (CCP high sensitive) in patients with rheumatoid arthritis. Immunol. Res. 2016. 64, 455–460 (IF : 2.905)

2015

8. Dutoit-Lefevre V, Dubucquoi S, Launay D, Sobanski V, Dussart P, Chafey P, Broussard C, Duban-Deweer S, Vermersch P, Prin L, Lefranc D*. An Optimized Fluorescence-Based Bidimensional Immunoproteomic Approach for Accurate Screening of Autoantibodies. PLoS One 2015;10. (IF : 2.806)

9. Pascal L, Hivert B, Trauet J, Deberranger E, Dessaint JP, Yakoub-Agha I, Labalette M*. A low effective dose of interleukin-7 is sufficient to maintain cord blood T cells alive without potentiating allo-immune responses. Biol Blood Marrow Transplant. 2015 Apr;21(4):625-31. (IF : 4,704)

10. Gatault S, Delbeke M, Driss V, Sarazin A, Dendooven A, Kahn JE, Lefèvre G, Capron M*. IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1. J Immunol. 2015;195:2483-92. (IF : 4.856)

11. Mortuaire G, Gengler I, Vandenhende-Szymanski C, Delbeke M, Gatault S, Chevalier D, Prin L, Capron M. Immune profile modulation of blood and mucosal eosinophils in nasal polyposis with concomitant asthma. Ann Allergy Asthma Immunol. 2015; 15: S1081-1206. (IF : 3.728)

12. Dubucquoi S, Proust-Lemoine E, Kemp EH, Ryndak A, Lefevre-Dutoit V, Bellart M, Saugier-Veber P, Duban-Deweer S, Wemeau JL, Prin L, Lefranc D*. Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1. Autoimmunity 2015. 48, 532–541(IF : 2,629)

2014

13. Sobanski V, Dauchet L, Lefevre G, Lambert M, Morell-Dubois S, Sy T, Hachulla E, Hatron PY, Launay D, Dubucquoi S*. Prevalence of Anti-RNA Polymerase III Antibodies in Systemic Sclerosis New Data From a French Cohort and a Systematic Review and Meta-Analysis. Arthritis Rheumatol 2014;66:407-17. (IF : 6,918)

14. Lanteri A, Sobanski V, Langlois C, Lefevre G, Hauspie C, Sanges S, Lambert M, Morell-Dubois S, Hatron PY, Hachulla E, Launay D, Dubucquoi S*. Serum free light chains of immunoglobulins as biomarkers for systemic sclerosis characteristics, activity and severity. Autoimmun Rev 2014;13:974-80. (IF : 8.961)

15. Choufi B, Trauet J, Thiant S, Labalette M, Yakoub-Agha I*. Donor-derived CD4+/CCR7+ T-cell partiel selective depletion does not alter acquired anti-infective immunity. Bone Marrow Transplant, 2014, 49 (5):611-615. (IF : 3.874)

16. Chérel M, Choufi B, Trauet J, Cracco P, Dessaint JP, Yakoub-Agha I, Labalette M*. Naïve subset develops the most important alloreactive response among human CD4+ T lymphocytes in human leukocyte antigen-identical related setting. Eur J Haematol. 2014;92(6):491-6. (IF : :2.653)

17. Lorenzi R, Pattou F, Beuscart JB, Grossin N, Lambert M, Fontaine P, Caiazzo R, Pigeyre M, Patrice A, Daroux M, Boulanger E, Dubucquoi S*. Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status. Diabetes Metab. 2014. 40, 356–362 (IF : 4,101)

18. Duchamp M, Sterlin D, Diabate A, Uring-Lambert B, Guérin-El Khourouj V, Le Mauff B, Monnier D, Malcus C, Labalette M, Picard C. B-cell subpopulations in children: National reference values. Immun Inflamm Dis. 2014 ;2(3):131-40.

2013

19. Lauwerys BR, Hachulla E, Spertini F, Lazaro E, Jorgensen C, Mariette X, Haelterman E, Grouard-Vogel G, Fanget B, Dhellin O, Vandepapelière P, Houssiau FA. Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid. Arthritis Rheum. 2013;65:447-56. (IF : 6,918)

20. Scherpereel A, Grigoriu BD, Noppen M, Gey T, Chahine B, Baldacci S, Trauet J, Copin MC, Dessaint JP, Porte H, Labalette M*. Defect in recruiting effector memory CD8+ T-cells in malignant pleural effusions compared to normal pleural fluid. BMC Cancer. 2013;13:324. (IF : 3,288)

21. Launay D, Dutoit-Lefevre V, Faure E, Robineau O, Hauspie C, Sobanski V, Hachulla E, Labalette M, Hatron PY, Dubucquoi S*. Effect of In Vitro and In Vivo Anakinra on Cytokines Production in Schnitzler Syndrome. PLoS One 2013;8. (IF : 2.806)

22. Maire C, Vercambre-Darras S, Devos P, D’Herbomez M, Dubucquoi S, Mortier L. Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort. J. Eur. Acad. Dermatol. Venereol. 2013. 27, 92–96 (IF : 3,528)